Intraocular hypotensive effect and action on aqueous humor dynamics of α-ergocryptine in ocular normotensive and in α-chymotrypsin-induced ocular hypertensive rabbits

Abstract

The aim of the present work was to compare the effect of α-ergocryptine on the intraocular pressure (IOP) and aqueous humor (AH) dynamics in ocular normotensive and α-chymotrypsin-induced ocular hypertensive rabbits. Our data suggest that α-ergocryptine decreases both tonographic outflow facility and, to a greater extent, AH inflow, which explains the final effect in ocular normotensive and in α-chymotrypsin-induced ocular hypertensive rabbits. Reductions in AH inflow observed after topical application of α-ergocryptine in α-chymotrypsin-induced ocular hypertensive rabbits can only be explained by a marked inhibition of active secretion of AH, since processes involved in AH formation, may be probably altered after α-chymotrypsin injection.